Tivatrainer

Validation Eleveld propofol in Tivatrainer(X)

Pharmacokinetic-pharmacodynamic model for propofol for broad application in anaesthesia and sedation D. J. Eleveld, P. Colin, A. R. Absalom and M. M. R. F. Struys Pump manufacturers have implemented, or are considering implementation, of the above model. The parameterisation of the model is rather complex but is available in TivatrainerX

Models, models and more models

Models, models and more models

After the era where Target Controlled Infusion was finally called Totally Confused Infusion because of the turmoil of models that were offered by the different pump manufactures for propofol: Marsh, Marsh with short keo, Schnider with fixed time to peak effect, Schnider with fixed keo, and Paedfusor,Kataria for children.

TivatrainerX: validation Remifentanil Kim-Obara-Egan

Disposition of Remifentanil in Obesity A New Pharmacokinetic Model Incorporating the Influence of Body Mass Tae Kyun Kim, M.D., Shinju Obara, M.D., Talmage D. Egan, M.D., and the Remifentanil Pharmacokinetics in Obesity Investigators (Anesthesiology 2017; 126:1019-32) When a pharmacokinetic or pharmacodynamic model is implemented in simulation